View Full Version : Bodyfat Setpoint Leptin Etc.

02-05-2011, 05:12 PM
I would like to get a discussion started regarding bodyfat setpoint and the hormones that might impact this. I know this is somewhat a broad discussion but things such as leptin and ghrelin are interesting to me in regards to bf setpoint, dieting, etc. I am mainly interested in hearing anecdotal accounts from people who are currently dieting down to a low bf percentage or studies that could provide interesting reading on the topic. I look forward to hearing from the members on the board. Thanks in advance for participating!

02-05-2011, 06:47 PM
It's a very interesting topic. From what I've uncovered it's somewhat depressing. There seems to be very little science to say it's possible to alter ones setpoint without the use of drugs.

Something extremely interesting to consider is that liposuction patients often binge their bodyfat right back. Which further suggests leptin is going to always win. It's a lot easier to rationalize a competitive bodybuilder who dieted to 4% not being able to control himself for weeks after the show and binging his bodyfat back towards his setpoint. But without leptin to blame, what would be the explanation for lipo patients with the same uncontrollable urges?

Another something interesting I came across just a few weeks ago was a 2004 study suggesting that melatonin in the presence of insulin lead to an increased excretion of expression of leptin (http://www.ncbi.nlm.nih.gov/pubmed/15572654). I'm actually guinea pigging this myself and taking 6mg of melatonin post workout with my shake that has 50g of dextrose in it. Obviously enough to cause in insulin secretion and I have always been known to get EXTREMELY hungry about one hour after this shake. I do have an opinion so far but I want to keep with it for a while longer, then go back to not supplementing with melatonin and perhaps back to with it one more time before I draw a personal opinion.

02-05-2011, 07:30 PM






i started typing an answer, and remembered this series of articles i'd read. they may take a while to wade through, but they address the topic better than i ever could.

personal experience: a setpoint sticks unless you maintain an uncomfortable weight for long enough for it to reset. i was around 175 and really wanted to be about 210, so i ate until i was uncomfortable daily for about 8 months to get to and maintain a bodyweight around 210-215. eventually i started gaining again up to about 225, and when i just started eating at a comfortable level again, i leveled off at about 210. ditto with 235. when i realized that much weight wasn't healthy on my frame, i dieted for about 8 solid months to get to and maintain a bodyweight of about 190, and now that i've resumed eating normally again, my bodyweight hovers around 200-205. resetting a setpoint SUCKS, but i've done it a few times.

02-05-2011, 08:21 PM
I am going to wade through those sites and get back tomorrow. I will do some research myself and see what I find, since it has been years since I researched the topic. I believe it to be quite interesting and something that anyone trying to get to a low bf percentage should consider when dieting.