Armidex vs Nolvadex

[Franco]

Okk, so I'm a long way off from going to the dark side, but have some questions

I have heard from different people that one of these anti-estrogen is better than the other, can they be better or are do they have different effects on the body?

Also, i've heard that depending on your cycle, it will decide which one is better for you?

[Life4ever]

Nolvadex doesnt inhibts estrogens, its SERM is breast tissue. Arimidex destroys estrogen LOL.

[Spiderman]

Yes, but then one must consider the high price of Arimidex. (2-4$ a tab) Hey, if you gots the cash go for it. ;)

[IBLiftin]

If you can find armi for 4 bucks a tab you must know some pretty good people. I've never seen it for less then 5-8 bucks a tab...

[Sinep]

Olay shxt FAngel... I was gonna post the "exact" same topic...

[Life4ever]

8 bucks? HOLY ****! LOL that is way to much.

[Spiderman]

Damn IB! I didn't think I low-balled it by that much! :eek:

[Tadger]

Originally posted by Life4ever
Nolvadex doesnt inhibts estrogens, its SERM is breast tissue. Arimidex destroys estrogen LOL.

It does not destroy estrogen really.... Arimidex (anastrozole) is non-steroidal aromitase inhibitor selectively inhibiting the conversion of androgens to estrogens. Anastrozole effectively inhibits the production of estrogens, including estrone, estradiol, and estrone sulfate.

The aromitase enzyme is responsible for converting androgens to estrogens in both males and females. Males do not have any way of producing significant quantities of estrogen directly so excess testosterone is converted to estrogen. When exogenous testosterone is introduced to the body, this too is subject to conversion by the aromitase/estrogen synthetase enzyme. Anastrozole competitively binds to the enzyme, occupying the testosterone binding site, thus making the enzyme inactive.

Now this is fairly expensive stuff... and in my opinion it's not worth taking until you're cycles have at the very least 500mg test/week along with d-bol... and that's if you're prone to gyno. I don't think you'll even be able to notice the difference at lower dosages... just not cost effective.

Nolvadex (tamoxifen) is a nonsteroidal estrogen agonist-antagonist that is structurally related to clomiphene. On breast tissue and the central nervous system, tamoxifen acts as an estrogen antagonist. It acts as an estrogen agonist on endometrium, bone, and lipids. Tamoxifen and several of its metabolites compete with estradiol for binding to cytoplasmic estrogen receptors in tissues such as breast, uterus, vagina, anterior pituitary, and tumors containing high concentrations of estrogen receptors. The effect on the breast tissue, bone, lipoproteins and pituitary are of significance to bodybuilders.

Tamoxifen also appears to oppose the proliferative effects of estrogen on breast epithelium by increasing production of inhibitory factors (e.g., transforming growth factor TGF-beta) and decreasing production of stimulatory factors (e.g., TGF-alpha, insulin-like growth factor-1) that influence breast cell growth.

Tamoxifen acts as an estrogen agonist in bone, inhibiting the reabsorbing activity of the osteoclasts thus preventing bone reabsorption and bone loss. While on a cycle this will prevent testosterone from increasing serum and urine concentrations of calcium at the expense of bone tissue resulting in a greater bone mineral density.

Tamoxifen, like estrogens, favorably affects serum cholesterol by decreasing total and low-density lipoprotein (LDL)-cholesterol concentrations. This is a definite advantage while on cycle as all AAS are sterol based and are broken down into their base structure upon deactivation. Although less favorably, tamoxifen appears to decrease high-density lipoprotein (HDL)-cholesterol concentrations and increase triglyceride concentrations.

Tamoxifen's effect on the pituitary stimulates the release of the hypothalamic gonadotropin-releasing factor with a resulting increase in secretion of pituitary gonadotropin.

In another less favorable light, tamoxifen's binding to nuclear chromatin appears to occur in an atypical manner and persisting for longer periods of time than the estrogen-receptor complexes. DNA synthesis and estrogen responses are thus markedly reduced. This is the reason that tamoxifen use should be limited during a cycle.

[Life4ever]

ok, that looked like a copy/paste LOL>..It does destroy estrogen in the body.

[Life4ever]

Originally posted by Tadger


. Anastrozole effectively inhibits the production of estrogens, including estrone, estradiol, and estrone sulfate.



Inhibit=stop, or as I call it, DESTROYS. It lowers estrogen in the body, that means it DESTROYS the estrogen.

[Sinep]

shxt Tadger if you typed all this from your head you're one smart mofo

[Spiderman]

Synonyms for the word Inhibit

Slow Down
Hold Back
Restrain
Slow Up
Reduce
Stall
Hinder
Hamper

I fail to see the word "Stop" or anything with the same meaning in that list.... :confused:

[Life4ever]

Bad wording, but it will eliminate estrogen in the body to a certain degree. have you seen any studies on it? 1 mg lowered estrogen in the body by almost 100% or more!

[Tadger]

Arimidex does not destroy estrogen... it slows the body's production of estrogen. Existing serum concentrations are not affected, only the ability of the estrogen synthetase/aromitase enzyme from completing it's job. There is no disputing that estrogen levels will drop... but that's only after deactivation by the liver or if it actually binds to a receptor and is then broken down.

I didn't cut n paste... but I sure as hell pulled out the cell biology books and looked at the patient handouts on that one. I started just trying to find the actual mechanism by which nolvadex works... and then I just kinda kept goin. I learned a few things myself on that one.

[TvR8oRage]

quality info, just what the doc ordered :D

[Life4ever]

Originally posted by Tadger
Existing serum concentrations are not affected

Sorry Tadger, they are affected. Maybe you need to look up some studies. Also, they were not done on anabolic steroid users, so it didnt have the aromitase factor, just ESTROGEN BEING EATEN AWAY.

[TvR8oRage]

Originally posted by Life4ever
Bad wording, but it will eliminate estrogen in the body to a certain degree. have you seen any studies on it? 1 mg lowered estrogen in the body by almost 100% or more!

100% right, you can control the sides but you will never stop the production of estrogen 100%, all studies show that the use of both compounds at best yelled around 60-70% effected on estogen levels, this in my opion is good enough to keep sides away what more do you want at least you dont have to buy a bra

[Life4ever]

LMFAO.. ok man.. whatever you say.

[Tadger]

Originally posted by Life4ever


Sorry Tadger, they are affected. Maybe you need to look up some studies. Also, they were not done on anabolic steroid users, so it didnt have the aromitase factor, just ESTROGEN BEING EATEN AWAY.

Hmm... care to explain the mechanism by which this occurs? I don't see how arimidex could have any effect on the estrogen levels already released into the blood stream. As far as I'm aware, arimidex just occupies the testosterone binding site on the aromitase enzyme preventing testosterone from being converted to estrogen. The half life of estrogen is naught but a few hours. Serum levels will drop quickly as estrogen is deactivated by the liver. I don't see how arimidex, a benzyltriazole derivative, could possibly interact with estrogen directly.

[Life4ever]

I dont know the mechanism, but I know it does. ill find the study if you think what im saying isnt right.

[Life4ever]

If you are really interested Tadger, go look in a PDR, I wish I still had access to one.

[gino]

I'd like to see that too. I always thought arimidex only prevented conversion to estrogen and didn't affect existing levels.