02-05-2001, 11:10 AM
Who's heard of it?
Apparently it is the gene that determines your genetic muscle limit (i.e. how much muscle you can naturally put on).
And apparently, evidence from tests show that Flex Wheeler's is mutated so that he responds very well to weighted activity (or some bloolocks like that...)
I thought it was just down to the amount of muscle enhancing substances he has circulating in his body!
If anyone wants to know a bit more on this then i can try and find the website i go it off and give you all the link to it.
I have a feeling that Anthony will be curious about this one...:)
02-05-2001, 11:20 AM
Interesting if it's true ... not sure why you thought I would be interested though ... ?
02-05-2001, 01:13 PM
Yes ive heard of it ( didnt want to tell anyone though :) )
I first saw a small article when they first discovered it in 1998, and i hadnt heard from it since. But last month i saw another one in musclemag. They said it was the future of bodybuilding. An injection of bacteria to attack the myostatin gene every 6 months would provide growth beyond imagination. On mice , the affect of taking oput the myostatin gene resulted in 232% bigger muscled mouse! Now those were big musclehead mice! What id like to know, is how could we be part of an experiment on humans :D
By the way it wouldnt supprise me that some bodybuilders already have acces to that kind of genetic manipulation.
Just look at Ronnie C. He grew out of proportion in two short years, just look at pictures of him 4 years aog, you wont believe it.
02-05-2001, 02:14 PM
Among the most potent growth factors produced locally in the muscles are
the prostaglandins. These quasi-hormones use fats as their raw materials.
Several classes of prostaglandins exist. We will mainly focus on the most
potent one, namely the prostaglandin F2 alpha or PGF2 for short.
If you apply PGF2 to a muscle cell, you are going to trigger a very strong
anabolic response. PGF2 has been used by veterinarians for years not only
to get animals pregnant but also to make them grow. A few daredevils
figured out that if it was making animals more muscular, it would make
bodybuilders bigger too. This was a big leap of faith as many drugs produce
wonderful effects in animals only to fail miserably in bodybuilders.
Clenbuterol is a good example of this: ultra potent in animals, deceptive in
humans. Amazingly enough, this time it worked wonders.
What I am going to reveal is true for men ONLY. Women will not get any
benefit from what I will describe below. Further, no women should EVER
touch this drug which will induce a very severe pain in their ovaries. As
men do not have ovaries, this is something that will not happen to them.
PGF2 and anabolism.
Many studies have demonstrated an anabolic effect of PGF2 in skeletal muscles of both humans and
animals. Paradoxically, PGF2 usage is still reserved to a bodybuilding elite and no one is willing to
divulge the precious secret edge. One of the most remarkable effects of PGF2 is that it mediates the
major part of the anabolic effects of insulin. By using PGF2, you can use far less insulin and get a
far stronger muscle building effect.
PGF2 and weak bodyparts.
The cardinal rule of PGF2 is to inject as far away as possible from the
intestine. You see, PGF2 induces a very strong contraction of the
intestine and the bladder (both smooth muscles). The major candidate as
a site of injection was the front shoulders. But by repeating injections in
the shoulders, bodybuilders soon ended up with grossly overdeveloped
front delts. They looked like walking monkeys. The rest of their body was
growing too, but not as fast as the muscles closest to the sites of
What this means is that if you want to develop a weak muscle, just inject PGF2 locally and watch
the muscle grow. We are talking about a real muscle growth and not an artificial swelling like
Synthol or Esiclene would induce. Calves are a muscle of choice. In fact, even if your calves failed
to grow no matter how much steroids and training you administered, PGF2 will solve your problem.
After a single cycle of PGF2, unresponsive calves start to respond to both training and steroids
even if they never did before.
The localized growth induced by PGF2 may appear magical, but there is a simple explanation. The
life cycle of the injected PGF2 is terribly short (minutes). Most of it will be destroyed in your lungs.
If you hit your right calf for example, this muscle will be exposed to a maximal concentration of
PGF2. As the prostaglandin rapidly leaks out of the calf and passes into the blood, it will quickly
reach the lungs where most of it will be destroyed. What is left of the PGF2 will be dispatched
evenly though your whole body. It means that the other muscles will be exposed to far less of the
anabolic effects of PGF2. So unless you want to make a weak point grow, you should rotate the
sites of injections frequently which as we will see is not a problem.
PGF2 is not to be confused with steroids.
You've probably realized by now that PGF2 produces growth in a radically different way from
steroids -- although I do not exclude that part of the anabolic actions of androgens are mediated by a
local release of PGF2. The way PGF2 should be used is therefore radically different from that of
androgens. steroid use is rather comfortable. You inject or swallow them once in a while and wait
for the growth to occur. This is not the case with PGF2. Their main drawback is precisely their
difficulty of administration. steroids once injected survive several days in your body. PGF2 will last
only several minutes though their stimulatory actions on anabolism will be far longer lasting
(hours). It means that frequent injections are compulsory. Ideally this would be five times per day,
30 minutes after meals.
You will also notice that once you have injected PGF2, the muscle which received it gets sore
almost immediately. If the muscle was already sore from training, that painful sensation may
become very intense. You definitely do not want to repeat injections at the very same location,
hence the necessity for rotation. By the same token, you will notice that you cannot inject in a
muscle and then train this muscle. PGF2 is algesic (a pain mediator). Therefore, the timing of
injections is key. You should wait for at least 2 to 3 days after you have trained a muscle to inject
it. Then you will have to wait for 24 hours before training this muscle. If your muscle is already
sore, I advise against using it as a site of injection as long as it hurts.
You will also learn that it is more comfortable to hit the outer part of the muscle than the inner part.
For example, it is less painful to hit the outer head of the triceps than the inner head that touches
your lats. Some bodyparts such as the biceps, the back, etc. are especially sensitive to the pain
sensation PGF2 will induce.
What about fat: PGF2 vs DNP?
We are told that DNP is the strongest thermogenic (temperature elevating) drug available. I dispute
this statement. Inject PGF2, wait for ten minutes and you will sweat profusely. In fact, your body
temperature will rise so much that you may feel very cold while a witness will get scared as you
feel so hot. By elevating your body temperature, PGF2 will burn up your fat at an accelerated rate.
Furthermore, unlike muscle cells, fat cells do not like to be exposed to PGF2. As a result, they die.
Mark this well: unlike a classical diet which makes each fat cell shrink, PGF2 kills fat cells. With
PGF2, you can say goodbye to your excess adipose tissue.
What about stacking steroids with PGF2?
If PGF2 is so powerful, why not stack it along with steroids for maximal effect? It looks like a neat
idea until you try. PGF2 potentiates the effects of androgens on muscles most likely by increasing
androgen receptor level. steroids also increase the effects of PGF2 probably by increasing the
density of muscle PGF2 receptors. You will end up with a combination that is too powerful.
Within two or three days on PGF2, you will notice that your muscles get very tight. You cannot find
harder muscles than muscles from a PGF2 user. It looks and feels great until you try to train. Within
three to four reps even with an empty bar, your muscles will get so pumped that you will not be able
to move. In fact, your training poundage are likely to drop severely. I have witnessed someone going
from 3 reps at 500 pounds in the incline bench press, to failing at 6 reps at 130 after a week of
(serious) PGF2 administration plus steroids. Do not worry though, your muscles will grow and you
will be able to resume heavy training once PGF2 is stopped. This pumping effect is too exaggerated
if you take steroids along with PGF2. So it is best to use the prostaglandins to grow when you're off
Is PGF2 safe?
The answer is clearly no, but neither is the use of steroids, insulin, clenbuterol, etc. By the way,
PGF2 is absolutely invisible at any drug test. What kind of side effects to expect? The first ones -- if
we except the elevation of temperature -- are that it will empty your guts of whatever they contain.
So make sure you have unrestricted use of a bathroom. This is going to last around 20 minutes.
What you do not want is to inject PGF2 into a vein! Learn to do the aspiration test. PGF2 is to be
injected intramuscularly with an insulin needle if you are lean enough. This is going to hurt like hell
and for a very long time (up to an hour) if you inject into a vein. You also may feel as if you had
some kind of cold in your throat. It is due to the vasoconstricting effect PGF2 has in your lungs.
Vomiting is a reported side effect but I have never heard of it in men.
You should start with a pretty low dosage (a half milligram) and see what happens. From there,
build up VERY slowly. Then, the sky is the limit. You can inject what is normally needed for several
cows and survive but believe me, you do not want to go through this. Do not forget to keep the vials
refrigerated. If you are new to PGF2, for simplicity choose the natural form and not an analog. PGF2
analogs have several advantages over straight PGF2 in that they have a longer half life and less
side effects, but some of them have no anabolic properties while others are more potent than
straight PGF2. Do not take a chance on that.
To sum up, I would like to paraphrase what Dan Duchaine has said about steroid users...
PGF2 users: Healthy, who knows? Big and lean, yes!
[Edited by Cackerot69 on 02-05-2001 at 04:22 PM]
02-05-2001, 03:53 PM
Originally posted by Anthony
not sure why you thought I would be interested though ... ?
Cause i know you are fascinated by strange and wonderful things such a s the serpinski's triangle etc...:)
02-05-2001, 05:54 PM
Wow, cack, where did you find that article and do you have more information on this stuff?
This is not the same thing as the myostatin gene though.
I just finished reading the article and relised that i read it before:( Still interesting though.
02-10-2001, 01:48 AM
MUTATIONS IN MYOSTATIN (GDF8) IN DOUBLE MUSCLED BELGIAN BLUE CATTLE
SMITH TIMOTHY P
BASS JOHN J
Recent studies of muscle development in mice have uncovered a gene that has major effects on the number of muscle fibers that develop prenatally. In its normal form the gene, called myostatin, acts as a negative regulator that tells the muscle precursor cells when to stop dividing and commence differentiation into fibers. Researchers at Johns Hopkins University produced mice with mutations in this gene that prevented its normal function. These mice had greatly enlarged muscles containing much higher number of fibers than normal, a phenotype similar to that seen in double- muscled cattle breeds such as Belgian Blue and Piedmontese. In several previous papers, we had mapped the gene causing double-muscling in cattle and shown that myostatin maps to the same location, which made it an excellent candidate for the gene causing muscle hypertrophy in these breeds. To test myostatin as a candidate, we looked to see if there is any difference in the expression of the mRNA in double muscled cattle, or any defect in the protein. In this paper we show that the level and timing of mRNA expression is indistinguishable between normal and heavy muscled animals. However, when we determined the sequence of the gene we discovered that both Belgian Blue and Piedmontese cattle have mutations in myostatin that are likely to inactivate the protein. We conclude that mutations in myostatin cause the double-muscle phenotype in cattle, a finding that may open the way to developing methods for manipulating muscle mass, fat deposition, and amount of connective tissue in meat animals.
Article thanks to http://www.nal.usda.gov/ttic/tektran/data/000008/51/0000085113.html
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