Igf

[Tadger]

I'm just wondering. Since a few sites are now selling IGF-1 LR3 as a "research" chem, I'm wondering if there's anyone out there that's done any research yet. Heh heh. I'm somewhat interested in the stuff... both the human grade or ghetto grade.

[BCC]

I'm with Tadger on this one. I've seen the same around and I'm also very curious.

[Severed Ties]

It definitely has peaked my interest but since I can't use anything now I haven't looked to deeply. Thus far their seems to be a great deal of positive feedback with no minimal reported side effects.

However it's the potential side effects that concern me so it would be a long time before I ever tried it.

ST

[CB]

I have seen it as well, and was wondering the same thing. But I'm with ST on waiting to see what sides may lie ahead down the road.

[Maki Riddington]

Interesting stuff, I've been mostly reading peoples journals in regards to using it.

[N4cer]

I don't have time for the particulars, but with 20mg dbol/day, 400mg 1-test cyp/wk, and 600mg 4-AD cyp/wk, I ran 40mcg/day. Gained 8lbs, and kept it all. This was a 3 wk cycle with no change in diet.

[JMD1648]

who has the freakin money they are asking though?!!
i would not risk losing that kind of money on a fake.

[BUFF STUFF]

B00mp

[IceRgrrl]

The problem that I can see with growth factors of any kind is that they are one of the regulators of the normal cell cycle and their presence/concentration often is part of the signalling pathway for cell growth/division. With too much growth factor in the system, abnormal cell growth/division might be a danger...worst case scenario being the type of abnormal cell growth/division that results in cancers and other problems.

Perhaps Delphi or someone with medical background can comment in more detail.

[PowerManDL]

That's a bigger possibility than most people realize.

The circulating form of IGF-1 is largely how GH mediates it's tissue-building effects. However, it doesn't do much if anything for spurring the growth of muscle. Muscle has it's own local form of IGF-1 (Mechano-Growth Factor, MGF) that is released in response to the standard muscle-building stimuli.

Could be potentially useful for building connective tissue, or cancer, but it won't be very effective for building muscle.

[Severed Ties]

IceR just articulated the concers behind IGF usage nicely. High IGF-1 levels are implicated in cancer studies however no direct correlation has been found thus far.

Power I believe IGF-1 causes muscle satellite cells to proliferate into muscle fibers as well as increase intramuscular glycogen storage which is how it exerts its anabolic effects.

ST

[IceRgrrl]

I thought about it/refreshed my information a bit, and it's a bad risk. IGF binds to tyrosine kinase receptors on the cell surface which initiates a complex cascade of events and signalling pathways inside the cell. One of these is the activation of the Ras pathway, which has its normal functions, but abnormal/improper Ras activation is implicated in 50-60% of human cancers. In other words, self-experimentation with IGF is a bit like playing Russian roulette.

It's just not as simple as "introduce substance A and effect B follows directly." Between the binding of growth factors and the cellular response are dozens upon dozens of steps and effects that weave into other cellular processes and activities of neighboring cells, tissues, and organs. The "research purposes" alluded to in the first post are referring to lab experiments done with cell and tissue cultures, not necessarily human cells/tissues. Introducing a growth factor into a petri dish of cells to measure some sort of cellular response is a MUCH different proposition than introducing it into a complex organism where entire systems are intertwined and effects are widespread.

IGF is different from steroids. Steroids signal the cell to produce the instructions for building proteins which are then synthesized by the cell and transported to the needed locations. The instructions for building these proteins and the mechanism for making them is part of your DNA and protein synthesis is part of normal cell activity. Steriods simply enhance this normal activity (though they can stress the body's systems in many ways, hence the need for caution). Growth factors, because of their control over normal cell growth and division, are much more dangerous because they can completely disrupt normal cell activity.

[tony touch]

i would never try it, colon cancer runs in my family.

it has promise but i think its probably very overrated for its expense just like GH.

i also worry about its stability, etc and if ur actually really getting what u paid for

[ONE]

I was looking into this also (sorry for the late post) but I'v heard great results from this product and rarely any sides. Since this was started a while back has anyone since then tried it. I found a site that sells it for 200$ for 1000mcg.

[BUFF STUFF]

one what were your great results?

as in gains?

body fat?

sides?

[ONE]

I haven't used it! my post says: I've heard great results from the use of it!
I was just wondering if anyone here has tried it?