Maxgain
11-23-2004, 03:20 PM
I am sure they are most likely on about fat gain but just in case.
From Medscape:
Nov. 9, 2004 (New Orleans) — A lean individual who gains more than 15 pounds in 15 years has a higher risk of developing metabolic syndrome than an overweight individual who maintains a stable weight, according to findings from a study presented here during the American Heart Association 2004 Scientific Sessions.
A consistently stable body mass index (BMI) will likely result in stable triglyceride, high-density lipoprotein (HDL) cholesterol, insulin, and blood pressure levels, announced Donald M. Lloyd-Jones, MD, ScM, assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine in Chicago, Illinois.
Over the course of 15 years, Dr. Lloyd-Jones and colleagues followed 1,277 male and 1,208 female patients (average age of 25 years at baseline) who were participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Subjects were stratified into three groups according to baseline BMI: 20.0 to 24.9; 25.0 to 29.9; and 30.0 to 34.9. BMI and measures of metabolic syndrome were measured at baseline and at years 2, 5, 7, 10, and 15.
Patients were further categorized on the basis of whether they gained weight during the course of the study. The "gain" group consisted of patients who gained more than 15 pounds during the 15-year study, whereas those whose BMI remained stable or decreased represented the "stable" group. The investigators assessed metabolic syndrome risk throughout the study.
Dr. Lloyd-Jones reported that 18% of patients were able to maintain or decrease their BMI, whereas 82% of subjects ended up in the gain group. This latter group had "steadily worsening levels of all risk factors," he said. Patients in the stable group had virtually unchanged risk. At the end of the study period, 3.6% of subjects in the stable group had metabolic syndrome, while 18.4% of those in the gain group had developed the syndrome.
"The most important thing we found was that regardless of baseline weight, risk factors didn't change much if weight remained stable," Dr. Lloyd-Jones told meeting attendees.
For those who gained weight, triglyceride levels increased by 4.31 mg/mL per year, HDL cholesterol levels decreased by 0.58 mg/dL, glucose levels rose by 0.30 mg/dL, insulin levels increased by 0.27 µg/mL, systolic blood pressure rose by 0.32 mm Hg, and diastolic blood pressure rose by 0.57 mm Hg per year — all significant differences from baseline. "This means that triglycerides will increase by 65 points in 15 years. That's a lot," Dr. Lloyd-Jones noted.
"For those patients who are overweight at baseline, the first goal is weight stabilization," Dr. Lloyd-Jones recommended. "The next goal would be weight loss."
Panel moderator Jorge Plutzky, MD, assistant professor of medicine at Harvard Medical School in Boston, Massachusetts, said, "I would underscore that maintaining weight is crucial.... When you see all the obesity in the young...and one quarter of the population is overweight..., in most of those cases, you can just substitute metabolic syndrome [for obesity]."
"Lean people at baseline who increased their weight had similar increases in risk factors to people who were heavy at baseline who gained weight. Those lean people are on a very dangerous track," Dr. Lloyd-Jones told Medscape.
AHA 2004 Scientific Sessions: Abstract 3567. Presented Nov. 8, 2004.
Reviewed by Gary D. Vogin, MD
From Medscape:
Nov. 9, 2004 (New Orleans) — A lean individual who gains more than 15 pounds in 15 years has a higher risk of developing metabolic syndrome than an overweight individual who maintains a stable weight, according to findings from a study presented here during the American Heart Association 2004 Scientific Sessions.
A consistently stable body mass index (BMI) will likely result in stable triglyceride, high-density lipoprotein (HDL) cholesterol, insulin, and blood pressure levels, announced Donald M. Lloyd-Jones, MD, ScM, assistant professor of preventive medicine at Northwestern University Feinberg School of Medicine in Chicago, Illinois.
Over the course of 15 years, Dr. Lloyd-Jones and colleagues followed 1,277 male and 1,208 female patients (average age of 25 years at baseline) who were participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Subjects were stratified into three groups according to baseline BMI: 20.0 to 24.9; 25.0 to 29.9; and 30.0 to 34.9. BMI and measures of metabolic syndrome were measured at baseline and at years 2, 5, 7, 10, and 15.
Patients were further categorized on the basis of whether they gained weight during the course of the study. The "gain" group consisted of patients who gained more than 15 pounds during the 15-year study, whereas those whose BMI remained stable or decreased represented the "stable" group. The investigators assessed metabolic syndrome risk throughout the study.
Dr. Lloyd-Jones reported that 18% of patients were able to maintain or decrease their BMI, whereas 82% of subjects ended up in the gain group. This latter group had "steadily worsening levels of all risk factors," he said. Patients in the stable group had virtually unchanged risk. At the end of the study period, 3.6% of subjects in the stable group had metabolic syndrome, while 18.4% of those in the gain group had developed the syndrome.
"The most important thing we found was that regardless of baseline weight, risk factors didn't change much if weight remained stable," Dr. Lloyd-Jones told meeting attendees.
For those who gained weight, triglyceride levels increased by 4.31 mg/mL per year, HDL cholesterol levels decreased by 0.58 mg/dL, glucose levels rose by 0.30 mg/dL, insulin levels increased by 0.27 µg/mL, systolic blood pressure rose by 0.32 mm Hg, and diastolic blood pressure rose by 0.57 mm Hg per year — all significant differences from baseline. "This means that triglycerides will increase by 65 points in 15 years. That's a lot," Dr. Lloyd-Jones noted.
"For those patients who are overweight at baseline, the first goal is weight stabilization," Dr. Lloyd-Jones recommended. "The next goal would be weight loss."
Panel moderator Jorge Plutzky, MD, assistant professor of medicine at Harvard Medical School in Boston, Massachusetts, said, "I would underscore that maintaining weight is crucial.... When you see all the obesity in the young...and one quarter of the population is overweight..., in most of those cases, you can just substitute metabolic syndrome [for obesity]."
"Lean people at baseline who increased their weight had similar increases in risk factors to people who were heavy at baseline who gained weight. Those lean people are on a very dangerous track," Dr. Lloyd-Jones told Medscape.
AHA 2004 Scientific Sessions: Abstract 3567. Presented Nov. 8, 2004.
Reviewed by Gary D. Vogin, MD