Beast
04-02-2007, 11:21 PM
My pharm prof touched on this today while discussing glucocorticoids.
Alternate day therapy is a method endocrinologists use with patients on chronic glucocorticoid therapy. Basically, you give a big dose of the steroid on day 1 followed by a smaller dose on day 2, big dose day 3 and smaller dose day 4, and so on. The rationale behind this is "to get the maximum pharm effect with minimal suppression of the hypothalamic-pituitary axis". I don't know how doing these alternating doses achieves that, but I was wondering if this could apply to AAS (keep in mind that glucocorticoids are steroids, so they affect protein synthesis).
What do you guys think?
Alternate day therapy is a method endocrinologists use with patients on chronic glucocorticoid therapy. Basically, you give a big dose of the steroid on day 1 followed by a smaller dose on day 2, big dose day 3 and smaller dose day 4, and so on. The rationale behind this is "to get the maximum pharm effect with minimal suppression of the hypothalamic-pituitary axis". I don't know how doing these alternating doses achieves that, but I was wondering if this could apply to AAS (keep in mind that glucocorticoids are steroids, so they affect protein synthesis).
What do you guys think?